In Depth

Designer babies: the arguments for and against

Debate intensifies as UK ethics body gives go-ahead to gene editing for non-medical reasons

Perfecting the genes of unborn babies could be “morally permissible” in the future, according to a new report by an influential medical ethics panel.

Under current laws, scientists are “only allowed to genetically edit human embryos for 14 days for research purposes, after which they must be destroyed, and it is illegal to implant them into a womb”, says The Daily Telegraph.

But the Nuffield Council on Bioethics says it could be acceptable to changes these laws, provided safeguards were met. The council’s report says that gene-editing procedures would be acceptable if they secure the future person’s welfare and do not increase disadvantages, discrimination or divisions within society.

“The potential use of genome editing to influence the characteristics of future generations is not unacceptable in itself,” said panel chair Karen Yeung, a professor of law, ethics and informatics at Birmingham University.

The discussion about the ethics of designer babies has been brought into sharp focus by the development of a technology called Crispr-Cas9 that “makes it remarkably simple to directly tinker with the human genome (the DNA sequence) of an early embryo”, says Wired.

When combined with IVF, “these new genetic tools allow scientists to change the DNA, which is the blueprint of a human embryo, when it consists of just one or a few cells”, the magazine explains.

Although technical hurdles remain, “advances in gene editing mean that it is possible to contemplate a time when embryos can be modified so that genetic diseases, or even genetic predispositions to disease, are eliminated”, reports The Times.

But opponents of designer babies “warn that permitting the practice could lead to the creation of super humans who have an unfair genetic advantage over others”, says German newspaper Deutsche Welle.

Here are brief summaries of arguments from both sides of the debate:

For
  • Since many diseases are caused by a single genetic mutation, those in favour ask why we shouldn’t edit the DNA of an embryo or the sperm and egg to remove the mutation entirely. “In effect this would remove a fault from humanity forever,” says The Times.  John Harris, a bioethicist at the University of Manchester, says: “The human genome is not perfect. It’s ethically imperative to positively support this technology.”
  • Those in favour argue that these scientific advances can be regulated in order to avert potential doomsday scenarios. “I still think you can try to regulate the technology,” Arthur Caplan, founding head of the Division of Bioethics at New York University, told USA Today. “It would be nice if we had an international group; set out some rules. It would be great if the scientific community - with religious and ethics and legal leaders - would set up some rules of how to operate. It would be nice if journal editors would say, ‘We’re not publishing anything unless these rules are followed.’”
  • In the US, a poll found that 83% of people thought genetic modification to make a baby more clever would be “taking medical advances too far”, according to MIT Technology Review, published by the Massachusetts Institute of Technology. However, proponents of genetic engineering argue that higher IQ is exactly what we should be considering. Nick Bostrom, an Oxford philosopher best known for his work on the risks of artificial intelligence, wrote in a 2013 paper that even a small number of “super-enhanced” individuals could “change the world through their creativity and discoveries, and through innovations that everyone else would use”.
Cons
  • There is the possibility that people will use the technology for “enhancements”, rather than fighting disease, American TV host John Oliver said recently on his show Last Week Tonight. “The more control people have over the ability to design their children, the bigger the moral questions that raises - up to and including, who decides what constitutes a genetic problem that needs to be ‘fixed’?”
  • Another issue is that of practicalities. Doctors say that just because we can change a gene does not mean we know what that change will do. “Most diseases are not caused by a single gene but many. Changing lots of genes could have lots of effects elsewhere,” reports The Times.
  • Any ethical debate “will also naturally run against practicalities like funding”, says The Independent. Many patients are subject already to a postcode lottery in accessing fertility treatment based on their local NHS funding, and “gene editing could initially be out of reach for all but the richest”, adds the newspaper. Acknowledging this problem, panel chair Professor Yeung said that if funding inequalities “were to exacerbate social injustice, in our view that would not be an ethical approach”.

Recommended

How high could inflation rise in the UK?
Pound coins and bank note
In Focus

How high could inflation rise in the UK?

Omicron at Christmas: the making or breaking of Boris Johnson
Boris Johnson turns on the Christmas tree lights at Downing Street
Why we’re talking about . . .

Omicron at Christmas: the making or breaking of Boris Johnson

Controversial transgender and migration views are not hate crimes, says report
Trans rights protest
In Depth

Controversial transgender and migration views are not hate crimes, says report

Dominic Cummings gatecrashes Downing Street Christmas party row
Dominic Cummings
Behind the scenes

Dominic Cummings gatecrashes Downing Street Christmas party row

Popular articles

Is World War Three looming?
Xi Jinping
In Depth

Is World War Three looming?

Vladimir Putin and his mysterious love life
Vladimir Putin and his now ex-wife Lyudmila Putina
Profile

Vladimir Putin and his mysterious love life

Is Boris Johnson’s authority ‘evaporating’?
Boris Johnson
Behind the scenes

Is Boris Johnson’s authority ‘evaporating’?

The Week Footer Banner